HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-Benzoimidazol-1-yl-4-phenyl-thiazole-5-carboxylic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 2-Benzoimidazol-1-yl-4-phenyl-thiazole-5-carboxylic acid ethyl ester | HCID 57595849 | — |
| Product | 2-Benzoimidazol-1-yl-4-phenyl-thiazole-5-carboxylic acid amide | HCID 23654387 | 13% |
Reaction Steps
2-Benzoimidazol-1-yl-4-phenyl-thiazole-5-carboxylic acid amide was prepared from 2-Benzoimidazol-1-yl-4-phenyl-thiazole-5-carboxylic acid ethyl ester (75 mg, 0.21 mmol) and ammonium hydroxide as described above in the general amide formation procedure. Preparative HPLC with trifluoroacetic acid, 9.1 mg, 13% yield. MS M/z 321 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504513B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-bb4775cc5c1145c0a1255bd2f894cd37 |
| Source note | uspto-grants-2009_03 |