5,6-Dimethylbenzimidazole → HCID 23653730, compound

HRID 1785483Notes

Reaction equation

HRID 1785483 reaction equation
[CH3:1][C:2]1[C:10]([CH3:11])=[CH:9][C:5]2[N:6]=[CH:7][NH:8][C:4]=2[CH:3]=1.C([O:14][C:15]([C:17]1[S:21][C:20](Cl)=[N:19][C:18]=1[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:16])C>>[CH3:1][C:2]1[C:10]([CH3:11])=[CH:9][C:5]2[N:6]([C:20]3[S:21][C:17]([C:15]([OH:16])=[O:14])=[C:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[N:19]=3)[CH:7]=[N:8][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 6755,6-DimethylbenzimidazoleHCID 130418162-Chloro-4-phenyl-5-thiazolecarboxylic acid ethyl ester

Product 1

HCID 23653730HCID 23653730, compound

Procedure

2-(5,6-Dimethylbenzoimidazol-1-yl)-4-phenylthiazole-5-carboxylic acid was prepared in a similar manner as that for Example 1 starting with the reaction of 5,6-dimethylbenzoimidazole and 2-Chloro-4-phenylthiazole-5-carboxylic acid ethyl ester. 1H-NMR(DMSO-D6) 8.82 (s, 1H); 7.98 (s, 1H); 7.82-7.92 (m, 2H); 7.58 (s, 1H); 7.42-7.52 (m, 3H); 2.39 (s, 3H); 2.38 (s, 3H). MS M/z 350 (M+1).

Sources & evidence

ORD record
ord-f6a29c8c6eea4dfdba4d9337dde91421
Source dataset
uspto-grants-2009_03
Patent number
US07504513B2

Reaction notes

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