反应详情

2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-phenyl-thiazole-5-carboxylic acid amide was prepared from 2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-phenyl-thiazole-5-carboxylic acid ethyl ester (80 mg, 0.20 mmol) and ammonia in ethanol (29 molar) as described above in the general amide formation procedure. The product was isolated by preparative HPCL: 7.7 mg, 36% yield. 1H-NMR (DMSO-D6) 8.78 (s, 1H); 7.80-7.90 (m, 4H); 7.789s, 1H); 7.40-7.55 (m, 3H); 7.38 (s, 1H); 3.84 (s, 3H); 3.83 (s, 3H). MS M/z 381 (M+1).

1. customThe product was isolated by preparative HPCL