反应详情

2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-phenyl-thiazole-5-carboxylic acid ethylamide was prepared from 2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-phenyl-thiazole-5-carboxylic acid ethyl ester (30 mg, 0.07 mmol) and ethylamine in methanol (2 molar) as described above in the general amide formation procedure. Product was isolated by preparative HPLC: 16 mg, 56%. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.81 (s, 1H); 8.53 (t, 1H); 7.88-7.69 (m, 3H); 7.55-7.44 (m, 3H); 7.40 (s, 1H); 3.88 (s, 3H); 3.85 (s, 3H); 3.25 (q, 2H); 1.08 (t, 3H). MS M/z 409 (M+1).

1. customProduct was isolated by preparative HPLC