5,6-Dimethoxybenzimidazole → HCID 57595856, compound

HRID 1785488Notes

Reaction equation

HRID 1785488 reaction equation
[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[CH:10][C:6]2[N:7]=[CH:8][NH:9][C:5]=2[CH:4]=1.Cl[C:15]1[S:16][C:17]([C:26]#[N:27])=[C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:19]=1.N1C2=CC3COCOC=3C=C2N=C1>>[CH3:13][O:12][C:11]1[C:3]([O:2][CH3:1])=[CH:4][C:5]2[N:9]([C:15]3[S:16][C:17]([C:26]#[N:27])=[C:18]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[N:19]=3)[CH:8]=[N:7][C:6]=2[CH:10]=1

Participants

4

Reactant 3

HCID 6012215,6-DimethoxybenzimidazoleHCID 201316552-Chloro-4-phenyl-thiazole-5-carbonitrileHCID 57595860HCID 57595860, compound

Product 1

HCID 57595856HCID 57595856, compoundYield 47%

Procedure

2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-phenyl-thiazole-5-carbonitrile (48.8 mg, yield 47%) was prepared from 5,6-dimethoxybenzimidazole (76 mg, 0.43 mmol) and 2-chloro-4-phenyl-thiazole-5-carbonitrile as described in Example 1 (63 mg, 0.28 mmol). MS M/z 363 (M+1)

Sources & evidence

ORD record
ord-99f1d4865b4b4902a6aeeb9077daab74
Source dataset
uspto-grants-2009_03
Patent number
US07504513B2

Reaction notes

Loading…