HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluorophenylboronic acid → 2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-(3-fluoro-phenyl)-thiazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| Reactant | 4-Bromo-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid methyl ester | HCID 57595851 | — |
| Product | 2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-(3-fluoro-phenyl)-thiazole-5-carboxylic acid | HCID 23653819 | 20% |
Reaction Steps
In a similar manner as described for Example 26, 4-bromo-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid methyl ester (40 mg, 0.1 mmol) and 3-fluorophenylboronic acid (21 mg, 0.15 mmol) gave 2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-(3-fluoro-phenyl)-thiazole-5-carboxylic acid (7.8 mg, 20%) as a white solid. MS 400 m/z (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504513B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-879b0c927d714358b78bab6d425e821d |
| Source note | uspto-grants-2009_03 |