3-Isopropylbenzeneboronic acid → HCID 23653917, compound

Participants

Reaction Steps

In a similar manner as described for Example 26, 4-bromo-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid methyl ester (40 mg, 0.1 mmol) and 3-isopropylphenylboronic acid (24.6 mg, 0.15 mmol) gave 2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-(3-isopropyl-phenyl)-thiazole-5-carboxylic acid (18.6 mg, 44%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 13.61 (br.s., 1 H); 8.83 (s, 1 H); 7.88 (s, 1 H); 7.83 (t, 1 H); 7.74 (dt, 1 H); 7.39 (s, 1 H); 7.40 (t, 1 H); 7.36 (dt, 1 H); 3.86 (s, 3 H); 3.85 (s, 3 H); 2.93-3.03 (m, 1 H); 1.26 (d, 6 H). MS m/z 424 (M+1 ).

Provenance & Evidence