Thiophene-3-boronic acid → HCID 23654381, compound

Participants

Reaction Steps

In a similar manner as described for Example 26, 4-bromo-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid methyl ester (40 mg, 0.1 mmol) and thiophene-3-boronic acid (19.2 mg, 0.15 mmol) gave 2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-thiophen-3-yl-thiazole-5-carboxylic acid (30.1 mg, 78%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 13.74 (br.s., 1 H); 8.84 (s, 1 H); 8.55 (dd, 1 H); 7.91 (dd, 1 H); 7.86 (s, 1 H); 7.66 (dd, 1 H); 7.40 (s, 1 H); 3.891 (s, 3 H); 3.85 (s, 3 H)═. MS m/z 388 (M+1).

Provenance & Evidence