2-Methylphenyl boronic acid → HCID 23654015, compound

Participants

Reaction Steps

In a similar manner as described for Example 26, 4-bromo-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid methyl ester (40 mg, 0.1 mmol) and 2-methylphenylboronic acid (20.4 mg, 0.15 mmol) gave 2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-o-tolyl-thiazole-5-carboxylic acid (22.5 mg, 57%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 13.43 (br.s., 1 H); 8.82 (s, 1 H); 7.68 (s, 1 H); 7.41 (d, 1 H); 7.40 (s, 1 H); 7.31-7.39 (m, 2 H); 7.27 (td, 1 H); 3.85 (s, 3 H); 3.81 (s, 3 H); 2.29 (s, 3 H). MS m/z 396 (M+1).

Provenance & Evidence