HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Chlorophenyl)boronic acid → 4-(3-Chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Chlorophenyl)boronic acid | HCID 2734323 | — |
| Reactant | HCID 57595851 | HCID 57595851 | — |
| Product | 4-(3-Chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid | HCID 23654019 | 21% |
Reaction Steps
In a similar manner as described for Example 26, 4-bromo-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid methyl ester (40 mg, 0.1 mmol) and 3-chlorophenylboronic acid (23.5 mg, 0.15 mmol) gave 4-(3-Chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid (8.6 mg, 21%) as a white solid. MS m/z 416 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504513B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-d9360d4309a44ed58a73f5b3e79e0c3c |
| Source note | uspto-grants-2009_03 |