3-Pyridinylboronic acid → HCID 57595853, compound

Participants

Reaction Steps

In a similar manner as described for Example 26, 4-bromo-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid methyl ester (40 mg, 0.1 mmol) and pyridine-3-boronic acid (18.4 mg, 0.15 mmol) gave 2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-pyridin-3-yl-thiazole-5-carboxylic acid (2.6 mg, 7%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 13.68 (br.s., 1 H); 9.07 (d, 1H); 8.85 (s, 1 H); 8.66 (dd, 1 H); 8.31 (dt, 1 H); 7.81 (s, 1 H); 7.55 (ddd, 1 H); 7.40 (s, 1 H); 3.86 (s, 3 H); 3.85 (s, 3 H). MS m/z 383 (M+1).

Provenance & Evidence