3-Vinylphenylboronic Acid (contains varying amounts of Anhydride) → 2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-(3-vinyl-phenyl)-thiazole-5-carboxylic acid

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Reaction Steps

In a similar manner as described for Example 26, 4-bromo-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid methyl ester (40 mg, 0.1 mmol) and 3-vinylphenylboronic acid (22 mg, 0.15 mmol) gave 2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-(3-vinyl-phenyl)-thiazole-5-carboxylic acid (26 mg, 64%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.84 (s, 1 H); 8.04 (t, 1 H); 7.85 (s, 1 H); 7.83 (dt, 1 H); 7.59 (dt, 1 H); 7.48 (t, 1 H); 7.40 (s, 1 H); 6.83 (dd, 1 H); 5.92 (dd, 1 H); 5.33 (dd, 1H); 3.86 (s, 3 H); 3.85 (s, 3 H). MS 408 m/z (M+1).

Provenance & Evidence