3,5-Dichlorophenylboronic acid → HCID 23654117, compound

Participants

Reaction Steps

In a similar manner as described for Example 26, 4-bromo-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid methyl ester (40 mg, 0.1 mmol) and 3,5-dichlorophenylboronic acid (27 mg, 0.15 mmol) gave 4-(3,5-Dichloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid (23 mg, 51%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.84 (s, 1 H); 8.15 (s, 2 H); 7.83 (s, 1 H); 7.73 (s, 1 H); 7.39 (s, 1 H); 3.89 (s, 3 H); 3.85 (s, 3 H). MS 450 m/z (M+1).

Provenance & Evidence