(3-Bromophenyl)boronic acid → HCID 23654118, compound

HRID 1785510Notes

Reaction equation

HRID 1785510 reaction equation
C[O:2][C:3]([C:5]1[S:9][C:8]([N:10]2[C:14]3[CH:15]=[C:16]([O:21][CH3:22])[C:17]([O:19][CH3:20])=[CH:18][C:13]=3[N:12]=[CH:11]2)=[N:7][C:6]=1Br)=[O:4].[Br:24][C:25]1[CH:26]=[C:27](B(O)O)[CH:28]=[CH:29][CH:30]=1>>[Br:24][C:25]1[CH:30]=[C:29]([C:6]2[N:7]=[C:8]([N:10]3[C:14]4[CH:15]=[C:16]([O:21][CH3:22])[C:17]([O:19][CH3:20])=[CH:18][C:13]=4[N:12]=[CH:11]3)[S:9][C:5]=2[C:3]([OH:2])=[O:4])[CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 2734318(3-Bromophenyl)boronic acidHCID 57595851HCID 57595851, compound

Product 1

HCID 23654118HCID 23654118, compoundYield 9%

Procedure

In a similar manner as described for Example 26, 4-bromo-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid methyl ester (40 mg, 0.1 mmol) and 3-bromophenylboronic acid (30 mg, 0.15 mmol) gave 4-(3-Bromo-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid (4.0 mg, 9%) as a white solid. MS 460 m/z (M+1).

Sources & evidence

ORD record
ord-c124c4e5794b44b4af072d5cc6728dfd
Source dataset
uspto-grants-2009_03
Patent number
US07504513B2

Reaction notes

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