3-Chloro-4-(trifluoromethyl)benzeneboronic acid → HCID 23654204, compound

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In a similar manner as described for Example 26, 4-bromo-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid methyl ester (40 mg, 0.1 mmol) and 3-chloro-4-trifluoromethylphenylboronic acid (33.7 mg, 0.15 mmol) gave 4-(3-Chloro-4-trifluoromethyl-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid (7.7 mg, 16%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 13.91 (br.s., 1 H); 8.85 (s, 1 H); 8.48 (d, 1 H); 8.31 (dd, 1 H); 7.89 (d, 1 H); 7.84 (s, 1 H); 7.39 (s, 1 H); 3.86 (s, 3 H), 3.85 (s, 3H). MS 484 m/z (M+1).

Provenance & Evidence