4-Vinylphenylboronic acid → HCID 23654289, compound

Participants

Reaction Steps

In a similar manner as described for Example 26, 4-bromo-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid methyl ester (40 mg, 0.1 mmol) and 4-vinylboronic acid (22.2 mg, 0.15 mmol) gave 2-(5,6-Dimethoxy-benzoimidazol-1-yl)-4-(4-vinyl-phenyl)-thiazole-5-carboxylic acid (15.2 mg, 37%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 13.69 (br.s., 1 H); 8.82 (s, 1 H); 7.95 (d, 2 H); 7.84 (s, 1 H); 7.60 (d, 2H); 7.39 (s, 1H); 6.82 (dd, 1 H); 5.97 (dd, 1 H); 5.37 (dd, 1 H); 3.86 (s, 3 H); 3.86 (s, 3 H). MS 408 m/z (M+1).

Provenance & Evidence