4-Amino-1,2,4-triazole → 4-(3-Chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid [1,2,4]triazol-4-ylamide

Participants

Reaction Steps

In a similar manner as described for Example 53, 4-(3-Chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid (41 mg, 0.1 mmol) and 4-amino-1,2,4-triazole (8.4 mg, 0.1 mmol, Aldrich) gave 4-(3-Chloro-phenyl)-2-(5,6-dimethoxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid [1,2,4]triazol-4-ylamide (2.4 mg, 5.0%) as a white solid. MS m/z 482 (M+1).

Provenance & Evidence