8-{5-[4-(Trifluoromethyl)phenyl]oxazol-2-ylamino}-3,4-dihydronaphthalen-2(1H)-one → 8-(5-p-Tolyloxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol

HRID 1785548Notes

Reaction equation

HRID 1785548 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([NH:13][C:14]3[CH:15]=[CH:16][CH:17]=[C:18]4[C:23]=3[CH2:22][C:21](=[O:24])[CH2:20][CH2:19]4)=[N:10][CH:9]=2)=[CH:4][CH:3]=1.FC(F)(F)C1C=CC(C2OC(NC3C=CC=C4C=3CC(=O)CC4)=NC=2)=CC=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([NH:13][C:14]3[CH:15]=[CH:16][CH:17]=[C:18]4[C:23]=3[CH2:22][CH:21]([OH:24])[CH2:20][CH2:19]4)=[N:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 119558408-{5-[4-(Trifluoromethyl)phenyl]oxazol-2-ylamino}-3,4-dihydronaphthalen-2(1H)-oneHCID 67229070HCID 67229070, compound

Product 1

HCID 119642628-(5-p-Tolyloxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol

Procedure

The title compound was prepared using the procedure as described in Example 2, substituting the product of Example 9C for the product of Example 1I. 1H NMR (DMSO-d6) δ 9.05 (s, 1H), 7.58 (m, 1H), 7.44 (m, 2H), 7.29 (s, 1H), 7.19 (m, 2H), 7.06 (t, 1H, J=7.5 Hz), 6.83 (d, 1H, J=7.0 Hz), 4.80 (d, 1H, J=4.0 Hz), 3.92 (m, 1H), 2.72-2.96 (m, 4H), 2.31 (s, 3H), 1.84 (m, 1H), 1.63 (m, 1H); MS (ESI+) m/z 321 (M+H).

Sources & evidence

ORD record
ord-df39debac6d94c92831d67bc336bea26
Source dataset
uspto-grants-2009_03
Patent number
US07504520B2

Reaction notes

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