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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785575Generated: October 26, 2026

HCID 53416493, compound → {8-[5-(2-Fluoro-4-trifluoromethylphenyl)oxazol-2-ylamino]-1,2,3,4-tetrahydronaphthalen-2-yl}carbamic acid tert-butyl ester

https://huagongshe.com/reaction/1785575

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 53416493HCID 53416493—
Reactant2-Ethoxy-8-isothiocyanato-1,4-dihydronaphthaleneHCID 86609612—
Reactant(8-Isothiocyanato-1,2,3,4-tetrahydronaphthalen-2-yl)carbamic acid tert-butyl esterHCID 86609614—
ReactantHCID 86609615HCID 86609615—
Product{8-[5-(2-Fluoro-4-trifluoromethylphenyl)oxazol-2-ylamino]-1,2,3,4-tetrahydronaphthalen-2-yl}carbamic acid tert-butyl esterHCID 6722876316%

Reaction Steps

The title compound was prepared using the procedure as described in Example 1H, substituting the product of Example 20F (415 mg, 1.36 mmol) for the product of Example 1F and the product of Example 22A (404 mg, 1.63 mmol) for the product of Example 1G. The crude product was purified by flash chromatography eluting with 20% to 60% EtOAc/hexanes which gave 107 mg (16%) of the title compound as a yellow solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504520B2
Source datasetuspto-grants-2009_03
ORD IDord-f927a438a17c4009a39ffd4602a2c56e
Source noteuspto-grants-2009_03