HCID 67228996, compound → HCID 67229659, compound

HRID 1785578Notes

Reaction equation

HRID 1785578 reaction equation
C(OC(=O)[NH:10][C:11]1[C:20]2[CH2:19][CH:18]([NH:21][S:22]([CH3:25])(=[O:24])=[O:23])[CH2:17][CH2:16][C:15]=2[CH:14]=[CH:13][CH:12]=1)C1C=CC=CC=1>CO.C(Cl)Cl>[NH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:20]=1[CH2:19][CH:18]([NH:21][S:22]([CH3:25])(=[O:24])=[O:23])[CH2:17][CH2:16]2

Participants

3

Reactant 1

HCID 67228996HCID 67228996, compound

Product 1

HCID 67229659HCID 67229659, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared using the procedure as described in Example 20E substituting the product of Example 23A (280 mg, 0.748 mmol) for the product Example 20D. Flash chromatography (5% to 10% CH3OH/CH2Cl2) gave 129 mg (72%) of the title compound as a white solid. 1H NMR (DMSO-d6) δ 7.20 (d, J=7.5 Hz, 1H), 6.79 (t, J=7.8 Hz, 1H), 6.43 (m, 1H), 6.30 (m, 1H), 4.74 (s, 2H), 3.55 (m, 1H), 2.99 (s, 3H), 2.75 (m, 3H), 2.22 (m, 1H), 1.95 (m, 1H), 1.58 (m, 1H); MS (DCI+) m/z 241 (M+H)+.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-69076bdd4b02416c8e9fe9ea490d68a5
Source dataset
uspto-grants-2009_03
Patent number
US07504520B2

Reaction notes

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