Pyridine → 4-Butylphenyl acetate

HRID 1785619Notes

Reaction equation

HRID 1785619 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([OH:11])=[CH:9][CH:10]=1.[CH3:12][C:13](OC(C)=O)=[O:14].N1C=CC=CC=1>ClCCl>[C:13]([O:11][C:8]1[CH:7]=[CH:6][C:5]([CH2:4][CH2:3][CH2:2][CH3:1])=[CH:10][CH:9]=1)(=[O:14])[CH3:12]

Participants

5

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 154204-Butylphenol

Product 1

HCID 127612574-Butylphenyl acetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 10 g of 4-n-butylphenol, 10 ml of Ac2O and 8 ml of pyridine is stirred at reflux in 10 ml of dichloromethane. After 2 hours, the medium is cooled to room temperature, diluted with dichloromethane, washed with water, washed with 1M HCl solution, washed with saturated CuSO4 solution, washed with water and dried over MgSO4. After evaporation, 10.8 g of the expected compound are recovered in the form of an oil.

Workup

  1. washwashed with water
  2. washwashed with 1M HCl solution
  3. washwashed with saturated CuSO4 solution
  4. washwashed with water
  5. dry with materialdried over MgSO4
  6. customAfter evaporation, 10.8 g of the expected compound
  7. customare recovered in the form of an oil

Sources & evidence

ORD record
ord-00c2832e1d7d435798cbf6b75d1754c1
Source dataset
uspto-grants-2009_03
Patent number
US07504511B2

Reaction notes

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