反应详情

To a stirred solution of 2,4′-dichlorobenzophenone (239 mmol) in methanol (400 mL) was added sodium borohydride (119 mmol) portionwise at 0° C. Reaction mixture was warmed to room temperature and stirred for 1 hour, then quenched with water and the methanol was removed under reduced pressure. The residue was diluted with dichloromethane (400 mL) and washed with water and brine, dried (MgSO4) and concentrated in vacuo to yield the product as an orange oil (47.1 g, 78%).

1. customReaction mixture
2. customquenched with water
3. customthe methanol was removed under reduced pressure
4. additionThe residue was diluted with dichloromethane (400 mL)
5. washwashed with water and brine
6. dry with materialdried (MgSO4)
7. concentrationconcentrated in vacuo