Isocyanate → 3-(4,4'-dichlorobenzhydryloxy)-N-(tert-butyl)azetidine-1-carboxamide

HRID 1785637Notes

Reaction equation

HRID 1785637 reaction equation
ClC1C=CC(C(OC2CNC2)C2C=CC(Cl)=CC=2)=CC=1.[N-]=C=O.Cl[C:25]1[CH:50]=[C:49]([Cl:51])[CH:48]=[CH:47][C:26]=1[CH:27]([O:35][CH:36]1[CH2:39][N:38]([C:40]([NH:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH2:37]1)[C:28]1[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=1>>[Cl:34][C:31]1[CH:32]=[CH:33][C:28]([CH:27]([O:35][CH:36]2[CH2:39][N:38]([C:40]([NH:42][C:43]([CH3:44])([CH3:45])[CH3:46])=[O:41])[CH2:37]2)[C:26]2[CH:47]=[CH:48][C:49]([Cl:51])=[CH:50][CH:25]=2)=[CH:29][CH:30]=1

Participants

4

Reactant 3

HCID 105034IsocyanateHCID 114420773-(2,4,4'-trichlorobenzhydryloxy)-N-(tert-butyl)azetidine-1-carboxamideHCID 689061393-(4,4'-Dichlorobenzhydryloxy)azetidine

Product 1

HCID 689042153-(4,4'-dichlorobenzhydryloxy)-N-(tert-butyl)azetidine-1-carboxamide

Procedure

This material was prepared from 3-(4,4′-dichlorobenzhydryloxy)azetidine (36) and the corresponding commercially available isocyanate, using the procedure described for compound (5) (53.0 mg, 45%).

Sources & evidence

ORD record
ord-0d1dbcdd8e2e4617aeb7f8af0ec02294
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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