HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-(2,2'-dichlorobenzhydryloxy)-N-(tert-butyl)azetidine-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-Butyl isocyanate | HCID 62412 | — |
| Reactant | 3-(2,2'-Dichlorobenzhydryloxy)azetidine hydrochloride | HCID 68907852 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(2,2'-dichlorobenzhydryloxy)-N-(tert-butyl)azetidine-1-carboxamide | HCID 68902433 | 44% |
Reaction Steps
A solution of 3-(2,2′-dichlorobenzhydryloxy)azetidine hydrochloride (68) (0.29 mmol), tert-butyl isocyanate (0.29 mmol) and triethylamine (0.58 mmol) in dichloromethane (3 mL) was shaken at room temperature overnight, quenched with water, filtered through a PTFE phase separator cartridge and reduced in vacuo to yield a colourless gum (52 mg, 44%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504522B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-30fb082b0b2e449a9dd68e4718af7da1 |
| Source note | uspto-grants-2009_03 |