Isocyanate → 3-(2,2'-dichlorobenzhydryloxy)-N-(allyl)azetidine-1-carboxamide

HRID 1785650Notes

Reaction equation

HRID 1785650 reaction equation
Cl.[Cl:2][C:3]1[CH:21]=[CH:20][CH:19]=[CH:18][C:4]=1[CH:5]([O:13][CH:14]1[CH2:17][NH:16][CH2:15]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[Cl:12].[N-]=C=O.ClC1C=CC=CC=1C(O[CH:37]1[CH2:40][N:39]([C:41](NC(C)(C)C)=[O:42])[CH2:38]1)C1C=CC=CC=1Cl>>[Cl:12][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[CH:5]([O:13][CH:14]1[CH2:17][N:16]([C:41]([NH:39][CH2:38][CH:37]=[CH2:40])=[O:42])[CH2:15]1)[C:4]1[CH:18]=[CH:19][CH:20]=[CH:21][C:3]=1[Cl:2]

Participants

4

Reactant 3

HCID 105034IsocyanateHCID 689024333-(2,2'-dichlorobenzhydryloxy)-N-(tert-butyl)azetidine-1-carboxamideHCID 689078523-(2,2'-Dichlorobenzhydryloxy)azetidine hydrochloride

Product 1

HCID 689060963-(2,2'-dichlorobenzhydryloxy)-N-(allyl)azetidine-1-carboxamide

Procedure

This material was prepared from 3-(2,2′-dichlorobenzhydryloxy)azetidine hydrochloride (68) and the corresponding commercially available isocyanate using the procedure described for compound (69).

Sources & evidence

ORD record
ord-5b213e1dff57421886c3cf511d31249d
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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