Isocyanate → 3-[2-(trifluoromethyl)-4'-chlorobenzhydryloxy]-N-(sec-butyl)azetidine-1-carboxamide

HRID 1785662Notes

Reaction equation

HRID 1785662 reaction equation
Cl.[F:2][C:3]([F:24])([F:23])[C:4]1[CH:22]=[CH:21][CH:20]=[CH:19][C:5]=1[CH:6]([O:14][CH:15]1[CH2:18][NH:17][CH2:16]1)[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1.[N-:25]=[C:26]=[O:27]>>[F:24][C:3]([F:2])([F:23])[C:4]1[CH:22]=[CH:21][CH:20]=[CH:19][C:5]=1[CH:6]([O:14][CH:15]1[CH2:18][N:17]([C:26]([NH:25][CH:4]([CH2:5][CH3:6])[CH3:3])=[O:27])[CH2:16]1)[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 105034IsocyanateHCID 689024633-[2-(Trifluoromethyl)-4'-chlorobenzhydryloxy]azetidine hydrochloride

Product 1

HCID 113851633-[2-(trifluoromethyl)-4'-chlorobenzhydryloxy]-N-(sec-butyl)azetidine-1-carboxamide

Procedure

This material was prepared from 3-[2-(trifluoromethyl)-4′-chlorobenzhydryloxy]azetidine hydrochloride (98) and the corresponding isocyanate using the procedure described for compound (10).

Sources & evidence

ORD record
ord-1e8613b69e7e43e0941ec43ef6a238b3
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

Loading…