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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785670Generated: October 30, 2026

1-(Diphenylmethyl)azetidin-3-ol → 1-Benzhydryl-3-[2-(trifluoromethyl)-4'-(methylthio)-benzhydryloxy]azetidine

https://huagongshe.com/reaction/1785670

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Diphenylmethyl)azetidin-3-olHCID 330448—
Reactant2-(Trifluoromethyl)-4'-(methylthio)benzhydrolHCID 49962978—
Reactant1-Benzhydryl-3-(2,4,4'-trichlorobenzhydryloxy)azetidineHCID 68903818—
Product1-Benzhydryl-3-[2-(trifluoromethyl)-4'-(methylthio)-benzhydryloxy]azetidineHCID 68902538—

Reaction Steps

This material was prepared from 1-benzhydryl-3-azetidinol (1) (15 mmol) and 2-(trifluoromethyl)-4′-(methylthio)benzhydrol (116) (30 mmol) using the procedure described for compound (3) (4.68 g, 60%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504522B2
Source datasetuspto-grants-2009_03
ORD IDord-0b028d06a76648998b6390e0ce260e03
Source noteuspto-grants-2009_03