HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonate Ion → 3-[2-(trifluoromethyl)-4'-(methylthio)benzhydryloxy]-N-(tert-butyl)-azetidine-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonate Ion | HCID 19660 | — |
| Reactant | tert-Butyl isocyanate | HCID 62412 | — |
| Reactant | 3-[2-Trifluoromethyl-4'-(methylthio)benzhydryloxy]azetidine hydrochloride | HCID 68904236 | — |
| Product | 3-[2-(trifluoromethyl)-4'-(methylthio)benzhydryloxy]-N-(tert-butyl)-azetidine-1-carboxamide | HCID 11201815 | — |
Reaction Steps
This material was prepared from 3-[2-trifluoromethyl-4′-(methylthio)benzhydryloxy]azetidine hydrochloride (118) (1.28 mmol), tert-butyl isocyanate (1.28 mmol) and mp-carbonate (2.62 mmol/g, 3.85 mmol) using the procedure described for compound (10) (433 mg, 75%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07504522B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-ec99783b1061463da6c8fc80e83e44c7 |
| Source note | uspto-grants-2009_03 |