Isocyanate → 3-[2-(trifluoromethyl)-4'-(methylthio)benzhydryloxy]-N-(benzyl)-azetidine-1-carboxamide

HRID 1785674Notes

Reaction equation

HRID 1785674 reaction equation
Cl.[F:2][C:3]([F:25])([F:24])[C:4]1[CH:23]=[CH:22][CH:21]=[CH:20][C:5]=1[CH:6]([O:15][CH:16]1[CH2:19][NH:18][CH2:17]1)[C:7]1[CH:12]=[CH:11][C:10]([S:13][CH3:14])=[CH:9][CH:8]=1.[N-:26]=[C:27]=[O:28]>>[F:25][C:3]([F:2])([F:24])[C:4]1[CH:23]=[CH:22][CH:21]=[CH:20][C:5]=1[CH:6]([O:15][CH:16]1[CH2:19][N:18]([C:27]([NH:26][CH2:3][C:4]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:5]=2)=[O:28])[CH2:17]1)[C:7]1[CH:12]=[CH:11][C:10]([S:13][CH3:14])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 105034IsocyanateHCID 689042363-[2-Trifluoromethyl-4'-(methylthio)benzhydryloxy]azetidine hydrochloride

Product 1

HCID 113407273-[2-(trifluoromethyl)-4'-(methylthio)benzhydryloxy]-N-(benzyl)-azetidine-1-carboxamide

Procedure

This material was prepared from 3-[2-trifluoromethyl-4′-(methylthio)benzhydryloxy]azetidine hydrochloride (118) and the corresponding isocyanate using the procedure described for compound (10).

Sources & evidence

ORD record
ord-4a4b1738bee54d4ea5525b7f8764cae7
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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