HRID1785676

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID330448

1-(Diphenylmethyl)azetidin-3-ol

C16H17NO

结构：Clc1ccc(C(OC2CN(C(c3ccccc3)c3ccccc3)C2)c2ccc(Cl)cc2Cl)cc1

HCID68903818

未命名化合物

HCID68907802

未命名化合物

PRODUCTS

生成物

结构：Fc1ccc(C(OC2CN(C(c3ccccc3)c3ccccc3)C2)c2ccc(Cl)cc2)c(C(F)(F)F)c1

HCID68906219

未命名化合物

PROCEDURE

实验过程

This material was prepared from 1-benzhydryl-3-azetidinol (1) (9.8 mmol) and 2-(trifluoromethyl)-4-fluoro-4′-chlorobenzhydrol (123) (19.7 mmol) using the procedure described for compound (3) (2.31 g, 45%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-240228535b35445996cf1f04636144d4
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07504522B2
来源说明: uspto-grants-2009_03

反应 SMILES

[CH:1]([N:14]1[CH2:17][CH:16]([OH:18])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:19][C:20]([F:38])([F:37])[C:21]1[CH:35]=[C:34]([F:36])[CH:33]=[CH:32][C:22]=1[CH:23](O)[C:24]1[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=1.C(N1CC(OC(C2C=CC(Cl)=CC=2)C2C=CC(Cl)=CC=2Cl)C1)(C1C=CC=CC=1)C1C=CC=CC=1>>[CH:1]([N:14]1[CH2:17][CH:16]([O:18][CH:23]([C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][CH:25]=2)[C:22]2[CH:32]=[CH:33][C:34]([F:36])=[CH:35][C:21]=2[C:20]([F:37])([F:38])[F:19])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1