Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785677Generated: October 25, 2026

3-(2,4'-Dichlorobenzhydryloxy)azetidine hydrochloride → 3-[2-(Trifluoromethyl)-4-fluoro-4'-chlorobenzhydryloxy]azetidine hydrochloride

https://huagongshe.com/reaction/1785677

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(2,4'-Dichlorobenzhydryloxy)azetidine hydrochlorideHCID 68902343—
Reactant1-Benzhydryl-3-[2-(trifluoromethyl)-4-fluoro-4'-chlorobenzhydryloxy]azetidineHCID 68906219—
Product3-[2-(Trifluoromethyl)-4-fluoro-4'-chlorobenzhydryloxy]azetidine hydrochlorideHCID 86611161—

Reaction Steps

This material was prepared from 1-benzhydryl-3-[2-(trifluoromethyl)-4-fluoro-4′-chlorobenzhydryloxy]azetidine (124) (3.8 mmol) using the procedure described for compound (9) (1.45 g, 97%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504522B2
Source datasetuspto-grants-2009_03
ORD IDord-c98931b763da4f8aaff60b5608364577
Source noteuspto-grants-2009_03