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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785683Generated: October 31, 2026

1-(Diphenylmethyl)azetidin-3-ol → 1-Benzhydryl-3-[2-(trifluoromethyl)benzhydryloxy]azetidine

https://huagongshe.com/reaction/1785683

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Diphenylmethyl)azetidin-3-olHCID 330448—
Reactant2-(Trifluoromethyl)benzhydrolHCID 2777401—
Reactant1-Benzhydryl-3-(2,4,4'-trichlorobenzhydryloxy)azetidineHCID 68903818—
Product1-Benzhydryl-3-[2-(trifluoromethyl)benzhydryloxy]azetidineHCID 68902469—

Reaction Steps

This material was prepared from 1-benzhydrol-3-azetidinol (1) (7.5 mmol) and 2-(trifluoromethyl)benzhydrol (131) (15 mmol) using the procedure described for compound (3) (1.81 g, 51%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504522B2
Source datasetuspto-grants-2009_03
ORD IDord-6ae82d8e4ec14b779d70ea3b11630b2b
Source noteuspto-grants-2009_03