Carbonate Ion → HCID 11329325, compound

HRID 1785690Notes

Reaction equation

HRID 1785690 reaction equation
Cl.[F:2][C:3]([F:28])([F:27])[C:4]1[CH:26]=[CH:25][CH:24]=[CH:23][C:5]=1[CH:6]([O:18][CH:19]1[CH2:22][NH:21][CH2:20]1)[C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]([F:17])([F:16])[F:15])=[CH:9][CH:8]=1.[C:29]([N:33]=[C:34]=[O:35])([CH3:32])([CH3:31])[CH3:30].C(=O)([O-])[O-]>>[F:28][C:3]([F:27])([F:2])[C:4]1[CH:26]=[CH:25][CH:24]=[CH:23][C:5]=1[CH:6]([O:18][CH:19]1[CH2:22][N:21]([C:34]([NH:33][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:35])[CH2:20]1)[C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]([F:17])([F:16])[F:15])=[CH:9][CH:8]=1

Participants

4

Reactant 3

HCID 19660Carbonate IonHCID 62412tert-Butyl isocyanateHCID 86611163HCID 86611163, compound

Product 1

HCID 11329325HCID 11329325, compound

Procedure

This material was prepared from 3-[2-(trifluoromethyl)-4′-(trifluoro-methoxy)benzhydryloxy]azetidine hydrochloride (141) (0.234 mmol), tert-butyl isocyanate (0.234 mmol) and MP-carbonate (2.62 mmol/g, 0.702 mmol) using the procedure described for compound (10) (78.7 mg, 69%).

Sources & evidence

ORD record
ord-24bf1fc2193b4aaf96bdacfbe9eaa3ab
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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