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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785694Generated: October 30, 2026

Cyclohexyl isocyanate → 3-[2-(trifluoromethyl)-4'-chlorobenzhydryloxy]-N-(cyclohexyl)-azetidine-1-carboxamide

https://huagongshe.com/reaction/1785694

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclohexyl isocyanateHCID 18502—
Reactant3-[2-(Trifluoromethyl)-4'-chlorobenzhydryloxy]azetidine hydrochlorideHCID 68902463—
Product3-[2-(trifluoromethyl)-4'-chlorobenzhydryloxy]-N-(cyclohexyl)-azetidine-1-carboxamideHCID 11419948—

Reaction Steps

This material was prepared from 3-[2-(trifluoromethyl)-4′-chlorobenzhydryloxy]azetidine hydrochloride (98) (0.55 mmol) and cyclohexyl isocyanate (0.55 mmol) using the procedure described for compound (10) (146 mg, 59%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504522B2
Source datasetuspto-grants-2009_03
ORD IDord-c04728cdfe2a4e1d948b3505171e4992
Source noteuspto-grants-2009_03