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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785696Generated: October 30, 2026

1-(Diphenylmethyl)azetidin-3-ol → Isohexane ethyl acetate

https://huagongshe.com/reaction/1785696

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Diphenylmethyl)azetidin-3-olHCID 330448—
Reactantp-Tolyl(2-(trifluoromethyl)phenyl)methanolHCID 13309099—
Reactant1-Benzhydryl-3-(2,4,4'-trichlorobenzhydryloxy)azetidineHCID 68903818—
ProductIsohexane ethyl acetateHCID 21882781—

Reaction Steps

This material was prepared from 1-benzhydryl-3-azetidinol (1) (7.5 mmol) and 2-(trifluoromethyl)-4′-methylbenzhydrol (149) (15 mmol) using the procedure described for compound (3). Flash column chromatography [SiO2; ethyl acetate-iso-hexane (5:95)] afforded a yellow gum (4.41 g) which was used in the next step without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504522B2
Source datasetuspto-grants-2009_03
ORD IDord-dcf7beab60df4f599652a6124e74a62a
Source noteuspto-grants-2009_03