1-Isocyanatoadamantane → HCID 11271958, compound

HRID 1785698Notes

Reaction equation

Cl.[F:2][C:3]([F:24])([F:23])[C:4]1[CH:22]=[CH:21][CH:20]=[CH:19][C:5]=1[CH:6]([O:14][CH:15]1[CH2:18][NH:17][CH2:16]1)[C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1.[C:25]12([N:35]=[C:36]=[O:37])[CH2:34][CH:29]3[CH2:30][CH:31]([CH2:33][CH:27]([CH2:28]3)[CH2:26]1)[CH2:32]2>>[F:24][C:3]([F:2])([F:23])[C:4]1[CH:22]=[CH:21][CH:20]=[CH:19][C:5]=1[CH:6]([O:14][CH:15]1[CH2:18][N:17]([C:36]([NH:35][C:25]23[CH2:34][CH:29]4[CH2:28][CH:27]([CH2:33][CH:31]([CH2:30]4)[CH2:32]2)[CH2:26]3)=[O:37])[CH2:16]1)[C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1

Participants

Reactant 2

HCID 20599951-Isocyanatoadamantane

HCID 68902478HCID 68902478, compound

Product 1

HCID 11271958HCID 11271958, compound

Procedure

This material was prepared from 3-[2-(trifluoromethyl)-4′-methylbenzhydryloxy]azetidine hydrochloride (151) (0.56 mmol) and 1-adamantyl isocyanate (0.56 mmol) using the procedure described for compound (10). The desired product was obtained as a white foam (264 mg, 94%).

Sources & evidence

ORD record: ord-d43547790faa43d19f3e126deec83131
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07504522B2

Reaction notes

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