tert-Butyl isocyanate → HCID 11475652, compound

HRID 1785699Notes

Reaction equation

HRID 1785699 reaction equation
Cl.[F:2][C:3]([F:24])([F:23])[C:4]1[CH:22]=[CH:21][CH:20]=[CH:19][C:5]=1[CH:6]([O:14][CH:15]1[CH2:18][NH:17][CH2:16]1)[C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1.[C:25]([N:29]=[C:30]=[O:31])([CH3:28])([CH3:27])[CH3:26]>>[F:24][C:3]([F:2])([F:23])[C:4]1[CH:22]=[CH:21][CH:20]=[CH:19][C:5]=1[CH:6]([O:14][CH:15]1[CH2:18][N:17]([C:30]([NH:29][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:31])[CH2:16]1)[C:7]1[CH:12]=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 62412tert-Butyl isocyanateHCID 68902478HCID 68902478, compound

Product 1

HCID 11475652HCID 11475652, compound

Procedure

This material was prepared from 3-[2-(trifluoromethyl)-4′-methylbenzhydryloxy]azetidine hydrochloride (151) (0.56 mmol) and tert-butyl isocyanate (0.56 mmol) using the procedure described for compound (10). The desired product was obtained as a colourless glass which gave a white solid on scratching (232 mg, 98%).

Sources & evidence

ORD record
ord-4a2a00d17af747b1afc4cf57ac1add84
Source dataset
uspto-grants-2009_03
Patent number
US07504522B2

Reaction notes

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