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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785707Generated: October 31, 2026

1-(Diphenylmethyl)azetidin-3-ol → 1-Benzhydryl-3-[2-(trifluoromethyl)-4'-fluorobenzhydryloxy]azetidine

https://huagongshe.com/reaction/1785707

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Diphenylmethyl)azetidin-3-olHCID 330448—
Reactant(4-Fluorophenyl)[2-(trifluoromethyl)phenyl]methanolHCID 49963912—
Reactant1-Benzhydryl-3-(2,4,4'-trichlorobenzhydryloxy)azetidineHCID 68903818—
Product1-Benzhydryl-3-[2-(trifluoromethyl)-4'-fluorobenzhydryloxy]azetidineHCID 68903208—

Reaction Steps

This material was prepared from 1-benzhydryl-3-azetidinol (1) (7.5 mmol) and 2-(trifluoromethyl)-4′-fluorobenzhydrol (160) (15 mmol) using the procedure described for compound (3). After basic aqueous workup, the crude product was used in the next step without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504522B2
Source datasetuspto-grants-2009_03
ORD IDord-62fbb1e06dcc4cf48b8456677bf4b467
Source noteuspto-grants-2009_03