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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785715Generated: October 31, 2026

4-(Methylsulfonyl)benzaldehyde → 2-(Trifluoromethyl)-4'-(methylsulfonyl)benzhydrol

https://huagongshe.com/reaction/1785715

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Methylsulfonyl)benzaldehydeHCID 220376—
Reactant(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanolHCID 68907806—
ReactantHCID 178506141HCID 178506141—
Product2-(Trifluoromethyl)-4'-(methylsulfonyl)benzhydrolHCID 68902462108.6%

Reaction Steps

This material was prepared from 2-(trifluoromethyl)phenylmagnesium bromide (14.5 mmol) and 4-(methylsulfonyl)benzaldehyde (2.68 g, 13.8 mmol) using the procedure described for compound (96). The product was obtained as an amber gum (4.95 g, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504522B2
Source datasetuspto-grants-2009_03
ORD IDord-dde7f526db1f4046aa203d05de1beca4
Source noteuspto-grants-2009_03