1-(Diphenylmethyl)azetidin-3-ol → 1-Benzhydryl-3-[2-(trifluoromethyl)-4'-(methylsulfonyl)benzhydryloxy]azetidine

Participants

Reaction Steps

This material was prepared from 1-benzhydryl-3-azetidinol (1) (6.9 mmol) and 2-(trifluoromethyl)-4′-(methylsulfonyl)benzhydrol (169) (13.8 mmol) using the procedure described for compound (3). After basic aqueous workup, the crude product was partially purified by flash column chromatography [SiO2; ethyl acetate-iso-hexane (30:70→80:20)] to afford an off-white foam (1.69 g) which was used directly in the next step without further purification.

Provenance & Evidence