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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1785719Generated: October 30, 2026

p-(Difluoromethoxy)benzaldehyde → 2-(Trifluoromethyl)-4'-(difluoromethoxy)benzhydrol

https://huagongshe.com/reaction/1785719

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-(Difluoromethoxy)benzaldehydeHCID 2736986—
Reactant(4-Chloro-2-(trifluoromethyl)phenyl)(phenyl)methanolHCID 68907806—
ReactantHCID 178506141HCID 178506141—
Product2-(Trifluoromethyl)-4'-(difluoromethoxy)benzhydrolHCID 6890248564%

Reaction Steps

This material was prepared from 2-(trifluoromethyl)phenylmagnesium bromide (16 mmol) and 4-(difluoromethoxy)benzaldehyde (2.09 mL, 15 mmol) using the procedure described for compound (96). The product was obtained as an amber gum (3.05 g, 64%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07504522B2
Source datasetuspto-grants-2009_03
ORD IDord-6218bdcc60e6473797af67e748ba2783
Source noteuspto-grants-2009_03