Benzocaine → HCID 22730143, compound

HRID 1785806Notes

Reaction equation

HRID 1785806 reaction equation
[C:1]1(=[O:13])[O:10][C:8](=O)[CH:7]2[CH2:11][CH2:12][C:2]1([C:4]2([CH3:6])[CH3:5])[CH3:3].[NH2:14][C:15]1[CH:25]=[CH:24][C:18]([C:19]([O:21][CH2:22]C)=[O:20])=[CH:17][CH:16]=1.CC1(C)CC(=O)OC(=O)C1>>[CH3:3][C:2]12[C:4]([CH3:5])([CH3:6])[CH:7]([CH2:11][CH2:12]1)[C:8](=[O:10])[N:14]([C:15]1[CH:16]=[CH:17][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:24][CH:25]=1)[C:1]2=[O:13]

Participants

4

Reactant 3

HCID 2337BenzocaineHCID 778133,3-Dimethylglutaric anhydrideHCID 948341,8,8-Trimethyl-3-oxabicyclo[3.2.1]octane-2,4-dione

Product 1

HCID 22730143HCID 22730143, compound

Procedure

The desired product was prepared by substituting methyl 4-aminobenzoate and (+/−)-camphoric anhydride for ethyl 4-aminobenzoate and 3,3-dimethylglutaric anhydride, respectively, in Example 19A. MS (DCI) m/e 333 (M+NH4)+.

Sources & evidence

ORD record
ord-379c5a2dac294d8093a956ae577f2be7
Source dataset
uspto-grants-2009_03
Patent number
US07504512B2

Reaction notes

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