Acetyl chloride → HCID 86592004, compound

HRID 1785872Notes

Reaction equation

HRID 1785872 reaction equation
[CH2:1]([C@H:3]1[CH2:12][C@@H:11](C(C)C(NC2C=CC=CC=2)=O)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]1[C:24]([C:26]1[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=1)=[O:25])C.[N:32]1[CH:37]=[CH:36][CH:35]=[C:34](Cl)[CH:33]=1.[O:39]1C=[CH:42][CH:41]=[C:40]1C(Cl)=O.[C:47](Cl)(=O)CC.C(Cl)(=O)C>>[CH3:1][C@H:3]1[CH2:12][C@@H:11]([N:32]([C:37]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:47]=2)[C:40](=[O:39])[CH2:41][CH3:42])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]1[C:24]([C:26]1[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=1)=[O:25]

Participants

6

Reactant 5

HCID 6367Acetyl chlorideHCID 122873-ChloropyridineHCID 62324Propionyl chlorideHCID 682422-Furancarbonyl chlorideHCID 86592005HCID 86592005, compound

Product 1

HCID 86592004HCID 86592004, compound

Procedure

(±)-Cis-[2-ethyl-1-(pyridine-3-carbonyl)-1,2,3,4-tetrahydro-quinolin-4-yl]-N-phenyl-propionamide was made following general procedure A substituting 3-pyridinyl chloride for 2-furoyl chloride and propionyl chloride for acetyl chloride.

Sources & evidence

ORD record
ord-4e35c2b5ec1047f3870898d97fed7bac
Source dataset
uspto-grants-2009_03
Patent number
US07504508B2

Reaction notes

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