Acetyl chloride → HCID 86601691, compound

HRID 1785873Notes

Reaction equation

HRID 1785873 reaction equation
FC1[CH:3]=[C:4]([CH:29]=CC=1OC)[C:5]([N:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C@H:10]([N:17]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:18](=[O:21])[CH2:19][CH3:20])[CH2:9][C@@H:8]1[CH3:28])=[O:6].[F:34][C:35]1C=C(C=CC=1OC)C(Cl)=O.O1C=CC=C1C(Cl)=O.[C:54](Cl)(=[O:57])[CH2:55][CH3:56].C(Cl)(=O)C>>[F:34][CH2:35][O:57][C:54]1[CH:29]=[C:4]([CH:3]=[CH:56][CH:55]=1)[C:5]([N:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C@H:10]([N:17]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:18](=[O:21])[CH2:19][CH3:20])[CH2:9][C@@H:8]1[CH3:28])=[O:6]

Participants

6

Reactant 5

HCID 6367Acetyl chlorideHCID 62324Propionyl chlorideHCID 682422-Furancarbonyl chlorideHCID 27792553-Fluoro-4-methoxybenzoyl chlorideHCID 86601692HCID 86601692, compound

Product 1

HCID 86601691HCID 86601691, compound

Procedure

(±)-Cis-N-[1-(3-fluoro-4-methoxy-benzoyl)-2-methyl-1,2,3,4-tetrahydro-quinolin-4-yl]-N-phenyl-propionamide was made following general procedure A substituting 3-fluoro-4-methoxybenzoyl chloride for 2-furoyl chloride and propionyl chloride for acetyl chloride.

Sources & evidence

ORD record
ord-367a282312274d3c879236cf8fb82974
Source dataset
uspto-grants-2009_03
Patent number
US07504508B2

Reaction notes

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