HCID 86592033, compound → HCID 86601693, compound

HRID 1785900Notes

Reaction equation

C([O:3][C:4](=[O:41])[C:5]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]([C:19](=[O:27])[C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)[C@@H:14]([CH3:28])[CH2:13][C@H:12]2[N:29]([C:34]1[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][CH:35]=1)[C:30](=[O:33])[CH2:31][CH3:32])([CH3:7])[CH3:6])C.ClC1C=CC(N(C(=O)CC)[C@H]2C3C(=CC=C(OCC(O)=O)C=3)N(C(=O)C3C=CC(F)=CC=3)[C@@H](C)C2)=CC=1>>[Cl:40][C:37]1[CH:38]=[CH:39][C:34]([N:29]([C:30](=[O:33])[CH2:31][CH3:32])[C@H:12]2[C:11]3[C:16](=[CH:17][CH:18]=[C:9]([O:8][C:5]([CH3:7])([CH3:6])[C:4]([OH:41])=[O:3])[CH:10]=3)[N:15]([C:19](=[O:27])[C:20]3[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=3)[C@@H:14]([CH3:28])[CH2:13]2)=[CH:35][CH:36]=1

Participants

Reactant 2

HCID 86592033HCID 86592033, compound

HCID 86601694HCID 86601694, compound

Product 1

HCID 86601693HCID 86601693, compound

Procedure

(±)-Cis-2-[4-[(4-chloro-phenyl)-propionyl-amino]-1-(4-fluoro-benzoyl)-2-methyl-1,2,3,4-tetrahydro-quinolin-6-yloxy]-2-methyl-propionic acid was prepared from (±)-cis-2-[4-[(4-chloro-phenyl)-propionyl-amino]-1-(4-fluoro-benzoyl)-2-methyl-1,2,3,4-tetrahydro-quinolin-6-yloxy]-2-methyl-propionic acid ethyl ester. The saponification conditions detailed in the procedure for the synthesis of (±)-cis-[4-[(4-chloro-phenyl)-propionyl-amino]-1-(4-fluoro-benzoyl)-2-methyl-1,2,3,4-tetrahydro-quinolin-6-yloxy]-acetic acid were used.

Sources & evidence

ORD record: ord-50b82e49bcce46dd8ab596a9d676d6fe
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07504508B2

Reaction notes

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