HRID1785900

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCC(=O)N(c1ccc(Cl)cc1)[C@@H]1C[C@H](C)N(C(=O)c2ccc(F)cc2)c2ccc(OCC(=O)O)cc21

HCID86592033

未命名化合物

结构：CCOC(=O)C(C)(C)Oc1ccc2c(c1)[C@H](N(C(=O)CC)c1ccc(Cl)cc1)C[C@H](C)N2C(=O)c1ccc(F)cc1

HCID86601694

未命名化合物

PRODUCTS

生成物

结构：CCC(=O)N(c1ccc(Cl)cc1)[C@@H]1C[C@H](C)N(C(=O)c2ccc(F)cc2)c2ccc(OC(C)(C)C(=O)O)cc21

HCID86601693

未命名化合物

PROCEDURE

实验过程

(±)-Cis-2-[4-[(4-chloro-phenyl)-propionyl-amino]-1-(4-fluoro-benzoyl)-2-methyl-1,2,3,4-tetrahydro-quinolin-6-yloxy]-2-methyl-propionic acid was prepared from (±)-cis-2-[4-[(4-chloro-phenyl)-propionyl-amino]-1-(4-fluoro-benzoyl)-2-methyl-1,2,3,4-tetrahydro-quinolin-6-yloxy]-2-methyl-propionic acid ethyl ester. The saponification conditions detailed in the procedure for the synthesis of (±)-cis-[4-[(4-chloro-phenyl)-propionyl-amino]-1-(4-fluoro-benzoyl)-2-methyl-1,2,3,4-tetrahydro-quinolin-6-yloxy]-acetic acid were used.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-50b82e49bcce46dd8ab596a9d676d6fe
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07504508B2
来源说明: uspto-grants-2009_03

反应 SMILES

C([O:3][C:4](=[O:41])[C:5]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[N:15]([C:19](=[O:27])[C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)[C@@H:14]([CH3:28])[CH2:13][C@H:12]2[N:29]([C:34]1[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][CH:35]=1)[C:30](=[O:33])[CH2:31][CH3:32])([CH3:7])[CH3:6])C.ClC1C=CC(N(C(=O)CC)[C@H]2C3C(=CC=C(OCC(O)=O)C=3)N(C(=O)C3C=CC(F)=CC=3)[C@@H](C)C2)=CC=1>>[Cl:40][C:37]1[CH:38]=[CH:39][C:34]([N:29]([C:30](=[O:33])[CH2:31][CH3:32])[C@H:12]2[C:11]3[C:16](=[CH:17][CH:18]=[C:9]([O:8][C:5]([CH3:7])([CH3:6])[C:4]([OH:41])=[O:3])[CH:10]=3)[N:15]([C:19](=[O:27])[C:20]3[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=3)[C@@H:14]([CH3:28])[CH2:13]2)=[CH:35][CH:36]=1