HCID 86592035, compound → HCID 58859789, compound

HRID 1785907Notes

Reaction equation

C([O:3][C:4](=O)[CH2:5][O:6][C:7]1[CH:16]=[C:15]2[C:10]([C@H:11]([N:29]([C:37](=[O:39])[CH3:38])[C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=3)[CH2:12][C@H:13]([CH3:28])[N:14]2[C:17](=[O:27])[C:18]2[CH:23]=[CH:22][C:21]([N:24]([CH3:26])[CH3:25])=[CH:20][CH:19]=2)=[CH:9][CH:8]=1)C.C(COC1C=C2C(=CC=1)N(C(=O)C1C=CC(F)=CC=1)[C@@H](C)C[C@H]2N(C1C=CC(Cl)=CC=1)C(=O)CC)(=O)[NH2:42]>>[C:37]([N:29]([C:30]1[CH:31]=[CH:32][C:33]([Cl:36])=[CH:34][CH:35]=1)[C@H:11]1[C:10]2[C:15](=[CH:16][C:7]([O:6][CH2:5][C:4]([NH2:42])=[O:3])=[CH:8][CH:9]=2)[N:14]([C:17](=[O:27])[C:18]2[CH:23]=[CH:22][C:21]([N:24]([CH3:25])[CH3:26])=[CH:20][CH:19]=2)[C@@H:13]([CH3:28])[CH2:12]1)(=[O:39])[CH3:38]

Participants

Reactant 2

HCID 86592035HCID 86592035, compound

HCID 86592045HCID 86592045, compound

Product 1

HCID 58859789HCID 58859789, compound

Procedure

(±)-Cis-2-[4-[acetyl-(4-chloro-phenyl)-amino]-1-(4-dimethylamino-benzoyl)-2-methyl-1,2,3,4-tetrahydro-quinolin-7-yloxy]-acetamide was prepared from (±)-cis-[4-[acetyl-(4-chloro-phenyl)-amino]-1-(4-dimethylamino-benzoyl)-2-methyl-1,2,3,4-tetrahydro-quinolin-7-yloxy]-acetic acid ethyl ester, via the same amidation procedure used in the synthesis of (±)-cis-N-[6-carbamoylmethoxy-1-(4-fluoro-benzoyl)-2-methyl-1,2,3,4-tetrahydro-quinolin-4-yl]-N-(4-chloro-phenyl)-propionamide.

Sources & evidence

ORD record: ord-69c1f7f68d5c4a3da58579363c6ad4b0
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07504508B2

Reaction notes

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