HCID 86592033, compound → HCID 131726428, compound

HRID 1785909Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([C:34](=[O:37])[CH2:35][CH3:36])[C@H:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([C:19](=[O:27])[C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)[C@@H:11]([CH2:28][O:29]C(=O)CC)[CH2:10]2)=[CH:4][CH:3]=1.ClC1C=CC(N(C(=O)CC)[C@H]2C3C(=CC=C(OCC(O)=O)C=3)N(C(=O)C3C=CC(F)=CC=3)[C@@H](C)C2)=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([C@H:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]([C:19](=[O:27])[C:20]3[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=3)[C@@H:11]([CH2:28][OH:29])[CH2:10]2)[C:34](=[O:37])[CH2:35][CH3:36])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 86592033HCID 86592033, compound

HCID 131726429HCID 131726429, compound

Product 1

HCID 131726428HCID 131726428, compound

Procedure

(±)-Cis-N-(4-chloro-phenyl)-N-[1-(4-fluoro-benzoyl)-2-hydroxymethyl-1,2,3,4-tetrahydro-quinolin-4-yl]-propionamide was prepared from (±)-cis-propionic acid 4-[(4-chloro-phenyl)-propionyl-amino]-1-(4-fluoro-benzoyl)-1,2,3,4-tetrahydro-quinolin-2-ylmethyl ester using the saponification conditions utilized in the synthesis of (±)-cis-[4-[(4-chloro-phenyl)-propionyl-amino]-1-(4-fluoro-benzoyl)-2-methyl-1,2,3,4-tetrahydro-quinolin-6-yloxy]-acetic acid.

Sources & evidence

ORD record: ord-5315f5b4e1174f36bad95a4458c713f7
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07504508B2

Reaction notes

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