Sodium borohydride → HCID 58859688, compound

HRID 1785936Notes

Reaction equation

HRID 1785936 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([N:9]([C@H:13]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]([C:23](=[O:32])[C:24]3[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=3)[C@@H:15]([CH3:33])[CH2:14]2)[C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][CH:8]=1)#[N:2].[BH4-].[Na+]>[Co](Cl)Cl>[NH2:2][CH2:1][C:3]1[CH:4]=[C:5]([N:9]([C@H:13]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]([C:23](=[O:32])[C:24]3[CH:25]=[CH:26][C:27]([O:30][CH3:31])=[CH:28][CH:29]=3)[C@@H:15]([CH3:33])[CH2:14]2)[C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 68921706HCID 68921706, compound

Product 1

HCID 58859688HCID 58859688, compound

Reagents, catalysts & solvents 1

HCID 24288Cobalt(II) chlorideCatalyst

Procedure

N-(3-cyanophenyl)-N-[(2S,4R)-1-(4-methoxybenzoyl)-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl]acetamide was further treated with cobalt(II)chloride and sodium borohydride (1 eq, 3 eq) to afford N-[3-(aminomethyl)phenyl]-N-[(2S,4R)-1-(4-methoxybenzoyl)-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl]acetamide.

Sources & evidence

ORD record
ord-9b1f9a27aafd474ebbeca7ef6221b5ab
Source dataset
uspto-grants-2009_03
Patent number
US07504508B2

Reaction notes

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