HCID 58859868, compound → HCID 58859767, compound

HRID 1786006Notes

Reaction equation

HRID 1786006 reaction equation
[C:1]([N:4]([C@H:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[N:25]([C:32](=[O:41])[C:33]2[CH:38]=[CH:37][C:36]([O:39][CH3:40])=[CH:35][CH:34]=2)[C@@H:24]([CH3:42])[CH2:23]1)[C:5]1[CH:10]=[CH:9][C:8]([NH:11]C(=O)OCC2C=CC=CC=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2]>CO.[Pd]>[NH2:11][C:8]1[CH:9]=[CH:10][C:5]([N:4]([C@H:22]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[N:25]([C:32](=[O:41])[C:33]3[CH:34]=[CH:35][C:36]([O:39][CH3:40])=[CH:37][CH:38]=3)[C@@H:24]([CH3:42])[CH2:23]2)[C:1](=[O:3])[CH3:2])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 58859868HCID 58859868, compound

Product 1

HCID 58859767HCID 58859767, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Benzyl (4-{acetyl[(2S,4R)-1-(4-methoxybenzoyl)-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl]amino}phenyl)carbamate was dissolved in MeOH and was added a catalytic amount of Palladium on Carbon (10%). The system was purged by Hydrogen gas, the subjected to 1 atm of H2 for 2 h. The reaction was quenched with air and filtered to give the title compound as a white solid.

Workup

  1. customThe system was purged by Hydrogen gas
  2. customThe reaction was quenched with air
  3. filtrationfiltered

Sources & evidence

ORD record
ord-40a6ccf4648e4083a27814efb89a04c0
Source dataset
uspto-grants-2009_03
Patent number
US07504508B2

Reaction notes

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