反应详情

(2S,4R)-(4-{4-[Acetyl-(4-chloro-phenyl)-amino]-2-methyl-3,4-dihydro-2H-quinoline-1-carbonyl}-phenoxy)-fluoro-acetic acid ethyl ester (100 mg) was dissolved in methanol/THF (1:1, 5 mL), and potassium hydroxide (1.0N, 1 mL) was added. After 1 hour, the reaction was acidified and extracted with methylene chloride. The organic layer was dried, filtered, and concentrated. The crude residue was purified by silica gel chromatography 100% ethyl acetate to 5% methanol/ethyl acetate gradient to afford the product.

1. extractionextracted with methylene chloride
2. customThe organic layer was dried
3. filtrationfiltered
4. concentrationconcentrated
5. customThe crude residue was purified by silica gel chromatography 100% ethyl acetate to 5% methanol/ethyl acetate gradient
6. customto afford the product